 | | 姓 名： | 庄树林 | | 学 历： | 博士 | | 职 务： | | | 职 称： | 教授 | | 部 门： | 环境健康研究所 | | 导 师： | 博导 | | 联系电话： | 0571-88982344 | | 电子邮箱： | shulin@zju.edu.cn | | 招生专业 | | 环境科学 | | 研究方向 | | 环境毒理学 | | 研究成果 | 近年来发表的部分论文：(*为通讯作者)
2020
Hao Wu, Liping Lu, Jiayan Chen, Chunlong Zhang, Weiping Liu, Shulin Zhuang*. Inhibited nitric oxide production of human endothelial nitric oxide synthase by nitrated and oxygenated polycyclic aromatic hydrocarbons. Environ Sci Technol, 2020, 54, 2922−2930.
2019
Xiaofang Zhang, Shixuan Cui, Liumeng Pan, Wenhua Dong, Mei Ma, Weiping Liu, Shulin Zhuang*. The molecular mechanism of the antagonistic activity of hydroxylated polybrominated biphenyl (OH-BB80) toward thyroid receptor β. Sci Total Environ, 2019, 697, 20: 134040.
Shixuan Cui, Xiaofang Zhang, Jinsong Liu, Lihong Zhou, Yukun Shang, Chunlong Zhang, Weiping Liu, Shulin Zhuang*. Natural sunlight-driven aquatic toxicity enhancement of 2,6-di-tert-butylphenol toward Photobacterium phosphoreum. Environ Pollut, 2019, 251:66-71.
2018
Tingjie Zhan, Liumeng Pan, Zhenfeng Liu, Jiayan Chen, Zhi-Wei Ge, Liping Lu, Xiaofang Zhang, Shixuan Cui, Chunlong Zhang, Weiping Liu, Shulin Zhuang*. Metabolic susceptibility of 2-chlorothioxanthone and its toxic effects on mRNA and protein expression and activities of human CYP1A2 and CYP3A4 enzymes. Environ Sci Technol, 2018, 52: 11904-11912.
Liping Lu, Tingjie Zhan, Mei Ma, Chao Xu, Jingpeng Wang, Chunlong Zhang, Weiping Liu, Shulin Zhuang*. Thyroid disruption by bisphenol S analogues via thyroid hormone receptor β: in vitro, in vivo and molecular dynamics simulation study. Environ Sci Technol, 2018, 52: 6617-6625.
Jiaying Wang, Jingpeng Wang, Jinsong Liu, Jianzhi Li, Lihong Zhou, Huanxin Zhang, Jianteng Sun, Shulin Zhuang*. The evaluation of endocrine disrupting effects of tert-butylphenols towards estrogenic receptor α, androgen receptor and thyroid hormone receptor β and aquatic toxicities towards freshwater organisms. Environ Pollut, 2018, 240: 396-402.
Shulin Zhuang, Leili Zhang, Tingjie Zhan, Liping Lu, Lu Zhao, Haifei Wang, Joseph Morrone, Weiping Liu*, Ruhong Zhou*. Binding specificity determines the Cytochrome P450 3A4 mediated enantioselective metabolism of metconazole. J Phys Chem B, 2018, 122: 1176-1184.
2017
Keke Ding, Xiaotian Kong, Jingpeng Wang, Liping Lu, Wenfang Zhou, Tingjie Zhan, Chunlong Zhang, Shulin Zhuang*. Side chains of parabens modulate antiandrogenic activity: In vitro and molecular docking studies. Environ Sci Technol, 2017, 51: 6452-6460.
Liumeng Pan, Liping Lu, Jingpeng Wang, Cunwu Zheng, Yujie Fu, Siyuan Xiao, Yating Jin, Shulin Zhuang*. The fungicide difenoconazole alters mRNA expression levels of human CYP3A4 in HepG2 cells. Environ Chem Lett, 2017, 15: 673-678.
Shulin Zhuang*, Xuan Lv, Liumeng Pan, Liping Lu, Zhiwei Ge, Jiaying Wang, Jingpeng Wang, Jinsong Liu, Weiping Liu, Chunlong Zhang*.Benzotriazole UV328 and UV-P showed distinct antiandrogenic activity upon human CYP3A4-mediated biotransformation. Environ Pollut, 2017, 220: 616-624.
Xuan Lv, Liumeng Pan, Jiaying Wang, Liping Lu, Weilin Yan, Yanye Zhu, Yiwen Xu, Ming Guo, Shulin Zhuang*. Effects of triazole fungicides on androgenic disruption and CYP3A4 enzyme activity. Environ Pollut, 2017, 222: 504-512.
Keke Ding, Liping Lu, Jiaying Wang, Jingpeng Wang, Minqiang Zhou, Cunwu Zheng, Jinsong Liu, Chunlong Zhang, Shulin Zhuang*. In vitro and in silico investigations of the binary-mixture toxicity of phthalate esters and cadmium (II) to Vibrio qinghaiensis sp.-Q67. Sci Total Environ, 2017, 580: 1078-1084.
Wenjing Zhang*, Haifei Wang, Xuan Lv, Keke Ding, Liumeng Pan. The molecular recognition paradigm of environmental chemicals with biomacromolecules. Curr Protein Pept Sci, 2017, 18: 41-47.
2016
Jianqiang Sun, Qianwen Wang, Shulin Zhuang, Anping Zhang*, Occurrence of polybrominated diphenyl ethers in indoor air and dust in Hangzhou, China: Level, role of electric appliances, and human exposure. Environ Pollut, 2016, 218: 942-949.
Jiaying Wang, Liumeng Pan, Shenggan Wu, Liping Lu, Yiwen Xu, Yanye Zhu, Ming Guo, Shulin Zhuang*. Recent advances on endocrine disrupting effects of UV filters. Int J Environ Res Publ Health, 2016, 13: 782.
Shulin Zhuang*, Haifei Wang, Keke Ding, Jiaying Wang, Liumeng Pan, Yanli Lu, Qingjun Liu, Chunlong Zhang. Interactions of benzotriazole UV stabilizers with human serum albumin: Atomic insights revealed by biosensors, spectroscopies and molecular dynamics simulations. Chemosphere,2016, 144: 1050-1059.
2015
Shulin Zhuang, Lingling Bao, Haifei Wang, Xulei Huang, Min Zhang, Xinyi Zhou, Chang Yang, Yuan Wu, Hua Naranmandura*. The involvement of ER-stress and ROS generation in difenoconazole-induced hepatocellular toxicity. Toxicol Res, 2015, 4:1195-1203.
Keke Ding, Huanxin Zhang, Haifei Wang, Xuan Lv, Liumeng Pan, Wenjing Zhang, Shulin Zhuang*. Atomic-scale investigation of the interactions between tetrabromobisphenol A, tetrabromobisphenol S and bovine trypsin by spectroscopies and molecular dynamics simulations. J. Hazard Mater., 2015, 299: 486-494.
Shulin Zhuang*, Zhisheng Zhang, Wenjing Zhang, Lingling Bao, Chao Xu*, Hu Zhang. Enantioselective developmental toxicity and immunotoxicity of pyraclofos toward zebrafish (Danio rerio). Aquatic Toxicol, 2015, 159: 119-126.
Lu Sun, Chen Zhang, Yingjie Chen, Xiao Li, Shulin Zhuang, Weihua Li, Guixia Liu, Philip W. Lee, Yun Tang*. In silico prediction of chemical aquatic toxicity with chemical category approaches and substructural alerts. Toxicol Res, 2015, 4: 452-463.
Chen Zhang, Feixiong Cheng, Lu Sun, Shulin Zhuang, Weihua Li, Guixia Liu, Philip W. Lee, Yun Tang*. In Silico prediction of chemical toxicity on avian species using chemical category approaches. Chemosphere, 2015, 122: 280-287.
Zhoulin Yao, Zuguang Li, Shulin Zhuang, Xiao ge Li, Mingfei Xu, Mei Lin, Qiang Wang, Hu Zhang*. Enantioselective determination of acaricide etoxazole in orange pulp, peel, and whole orange by chiral liquid chromatography with tandem mass spectrometry. J Sep Sci, 2015, 38: 599-604.
潘柳萌, 吕翾, 庄树林*. 分子动力学模拟在有机污染物毒性作用机制研究中的应用. 科学通报, 2015, 19: 1781-1788.（被选为封面论文）
2014
Shulin Zhuang, Chunlong Zhang, Weiping Liu*. Atomic insights into distinct hormonal activities of bisphenol A analogues toward PPARγ and ERα receptors. Chem. Res. Toxicol., 2014, 27(10): 1769-1779.
Yanli Lu, Yao Yao, Qian Zhang, Diming Zhang, Shulin Zhuang, Hongliang Li, Qingjun Liu. Olfactory biosensor for insect semiochemicals analysis by impedance sensing ofodorant-binding proteins on interdigitated electrodes. Biosens Bioelectron, 2014,pii:S0956-5663(14)00792-1.
Chen Weng, Yuxia Fu, Hongtao Jiang, Shulin Zhuang, Hongliang Li. Binding interaction between a queen pheromone component HOB and pheromone binding protein ASP1 of Apis cerana. Int J Biol Macromol, 2014, 72C: 430-436.
Hu Zhang, Xiangyun Wang, Xinquan Wang, Mingrong Qian, Mingfei Xu, Hao Xu, Peipei Qi, Qiang Wang*, Shulin Zhuang*. Enantioselective determination of carboxyl acid amide fungicide mandipropamid in vegetables and fruits by chiral LC coupled with MS/MS. J. Sep. Sci., 2014, 37: 211-218.
Yanqing Wang*, Chunyun Tan, Shulin Zhuang, Pengzhan Zhai, Yuncui, Qiuhu Zhou, Hongmei Zhang, Zhenghao Fei. In vitro and in silico investigations of the binding interactions between chlorophenols and trypsin. J. Hazard Mater, 2014, 278: 55-65.
Chen Weng, Yuxia Fu, Hongtao Jiang, Shulin Zhuang, Honglian Li*. Binding interaction between a queen pheromone component HOB and pheromone binding protein ASP1 of Apis cerana. Int J Biol Macromol, 2014,72C: 430-436.
2013
Feng Zhang, Jing Zhang, Changlun Tong, Yadong Chen, Shulin Zhuang*, Weiping Liu. Molecular interactions of benzophenone UV filters with human serum albumin revealed by spectroscopic techniques and molecular modeling. J. Hazard Mater., 2013, 263(2): 618-626.
Shulin Zhuang, Lingling Bao, Apichart Linhananta, Weiping Liu*. Molecular modeling revealed that ligand dissociation from thyroid hormone receptors is affected by receptor heterodimerization. J. Mol. Graph. Model., 2013, 44: 155-160.
Jing Zhang, Shulin Zhuang*, Changlun Tong, and Weiping Liu*. Probing the molecular interaction of triazole fungicides with human serum albumin by multispectroscopic techniques and molecular modeling. J. Agric. Food. Chem., 2013, 61: 7203-7211.
Hongliang Li, Linya Zhang, Cuixia Ni, Hanwu Shang, Shulin Zhuang*, Jianke Li*. Molecular recognition of floral volatile with two olfactory related proteins in the Eastern honeybee (Apis cerana) Int. J. Biol. Macromol., 2013, 56: 114-121.
Qingjun Liu, Hua Wang, Hongliang Li, Jing Zhang, Shulin Zhuang, FenniZhang,K. Jimmy Hsia, Ping Wang*. Impedance sensing and molecular modeling of an olfactory biosensor based on chemosensory proteins of honeybee. Biosens. Bioelectron., 2013, 40: 174-179.
2012
Shulin Zhuang, Jing Zhang, Yuezhong Wen, Chunlong Zhang, Weiping Liu*. Distinct mechanisms of endocrine disruption of DDT-related pesticides toward estrogen receptor α and estrogen-related receptor γ. Environ. Toxicol. Chem., 2012, 31: 2597-2605.
Hu Zhang, Xinquan Wang, Shulin Zhuang, Mingrong Qian, Kezhi Jiang, Xiangyun Wang, Hao Xu, Peipei Qi, Qiang Wang*. Enantioselective separation and simultaneous determination of fenarimol and nuarimol in fruits, vegetables, and soil by liquid chromatography–tandem mass spectrometry. Anal. Bioanal .Chem., 2012, 404: 1983-1991.
Hu Zhang, Xinquan Wang, Shulin Zhuang, Nuo Jin, Xiangyun Wang, Mingrong Qian*, Hao Xu, Peipei Qi, Qiang Wang, and Minghua Wang*. Enantioselective Analysis and Degradation Studies of Isocarbophos in Soils by Chiral Liquid Chromatography-Tandem Mass Spectrometry. J .Agric. Food. Chem., 2012, 60:10188-95.
Ting Ran, Tao Lu, Haoliang Yuan, Haichun Liu, Jian Wang, Weiwei Zhang, Ying Leng, Guowu Lin, Shulin Zhuang,Yadong Chen*. A selectivity study on mTOR/PI3Kα inhibitors by homology modeling and 3D-QSAR. J. Mol. Model., 2012, 18: 171-186.
张志生, 张靖, 张丰, 庄树林* ERα和ERβ介导的有机磷农药雌激素效应差异分析. 环境科学学报, 2012, 32(12):3006-3014.
2011
Yuezhong Wen, Chandan Li, Zhaohua Fang, Shulin Zhuang*, Weiping Liu. Elucidation of the enantioselective enzymatic hydrolysis of chiral herbicide dichlorprop methyl by chemical modification. J. Agric .Food. Chem., 2011, 59: 1924-1930.
Jing Liu, Yan Yang, Shulin Zhuang, Ye Yang, Feixue Liu, Weiping Liu*. Enantioselective endocrine-disrupting effects of bifenthrin on hormone synthesis in rat ovarian cells. Toxicology., 2011, 290: 42-49.
Shulin Zhuang, Jing Zhang, Feng Zhang, Zhisheng Zhang,Yuezhong Wen,Weiping Liu*. Investigation of the diastereomerism of dihydrobenzoxathiin SERMs for ER alpha by molecular modeling. Bioorg. Med. Chem. Lett., 2011, 21: 7298-7305.
Shulin Zhuang, Weiping Liu*. Investigation of the binding specificity of Erbin-PDZ affinity clamp by molecular dynamics simulations. Comput. Theor. Chem., 2011, 963: 448-452.
Other selected publications
Shulin Zhuang, Apichart Linhananta, Hongbin Li*. Phenotypic effects of Ehlers-Danlos syndrome-associated mutation on the FnIII domain of tenascin-X. Protein .Sci., 2010, 19: 2231-2239.
Shulin Zhuang, Qing Peng, Yi Cao, Hongbin Li*. Modulating the mechanical stability of extracellular matrix protein tenascin-C in a controlled and reversible fashion. J .Mol .Biol., 2009, 390: 820-829.
Shulin Zhuang, Jianwei Zou*, Yongjun Jiang, Xiang Mao, Bing Zhang, Haichun Liu, Qingsen Yu.Some insights into the stereochemistry of inhibition of macrophage migration inhibitory factor with 2-fluoro-p-hydroxycinnamate and its analogues from molecular dyynamics simulations. J . Med .Chem., 2005, 48, 7208-7214. | | 个人简介 | 男，1977年生，籍贯山东，理学博士，教授，博士生导师。浙江大学第一批“求是青年学者”，2011年入选“浙江大学优秀青年教师资助计划（紫金计划）”，浙江大学2013年“五好”导学团队导师组成员，浙江大学2013-2014学年优秀班主任、浙江大学2011-2012学年优秀班主任。2004年2月获浙江大学有机合成专业硕士学位；2007年3月获浙江大学化学生物学专业博士学位；2007年9月至2010年5月在加拿大英属哥伦比亚大学（University of British Columbia）化学系从事博士后研究工作，2010年6月至今在环资学院环境科学研究所工作。
目前主要从事环境毒理学研究，主持或承担了国家自然科学基金（青年和面上项目）、国家高技术研究发展计划（863）子课题、浙江省重大科技专项重点社会发展项目、教育部博士点基金（新教师）等项目7项。在污染物的综合生物毒性快速评估、新兴污染物的毒性甄别、P450酶介导的污染物生物转化及其分子机制方面做了系统研究工作，已在国内外著名学术期刊上发表SCI收录论文40余篇，多次获邀在国际及国内重要学术会议上做口头学术报告。 |
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