 | | 姓 名： | 李保海 | | 学 历： | 博士 | | 职 务： | | | 职 称： | 研究员 | | 部 门： | 农业化学研究所 | | 导 师： | 博导 | | 联系电话： | | | 电子邮箱： | bhli@zju.edu.cn | | 招生专业 | | | 研究方向 | | 植物营养分子生物学、植物营养与群体遗传、根系环境生物学 | | 研究成果 | 李保海研究员一直从事植物营养生物学方向研究，重点研究植物适应营养逆境的分子生理机制，致力于将植物营养学与细胞生物学、正反向遗传学和群体遗传学等相结合，深入研究根系在营养逆境中如何维持生长与营养运输的分子生理作用机制及其在群体间应答差异的遗传基础，发现了调控根系凯氏带形成的新基因LOTR1，并揭示了木栓质在侧根原基冒出处（内皮层凯氏带断裂）阻控质外体养分离子自由扩散的新功能；鉴定到首个控制植物群体根系耐铁毒自然变异的主效基因GSNOR及其在不同植物物种间耐铁毒的保守性功能，证明了GSNOR通过抑制铁依赖的亚硝基化胁迫和氧化胁迫来维持根系分生区的生长。以第一作者（含共同第一）或通讯作者在Nature Communications, Current Biology, Trends in Plant Science, Plant Physiology, New Phytologist, Plant Cell & Environment等国际著名期刊发表高水平SCI论文7篇，并主持完成国内外4个基金项目。
加盟浙江大学植物营养学科后，紧扣农业可持续发展等国家重大战略需求，结合自身研究基础和特长，拟继续开展植物（拟南芥、百脉根及水稻等）根系适应土壤逆境的分子生理、遗传发育等调控机制研究，重点解析植物群体对土壤逆境适应性自然变异的遗传机制和根系应答土壤逆境中的内皮层屏障发育与调控功能，为提高作物适应土壤逆境能力和养分利用效率提供理论依据。
（一）发表论文
Shikanai Y, Yoshida R, Hirano T, Enomoto Y, Li B, Asada M, Yamagami M, Yamaguchi K, Shigenobu S, Tabata R, Sawa S, Okada H, Ohya Y, Kamiya T, Fujiwara T*. Callose synthesis suppresses cell death induced by low-calcium conditions in leaves. Plant Physiology, Published February 2020. DOI: https://doi.org/10.1104/pp.19.00784.
Li B*, Sun L, Huang J, Goschl C, Shi W, Chory J & Busch W*. GSNOR provides plant tolerance to iron toxicity via preventing iron-dependent nitrosative and oxidative cytotoxicity. Nature Communications, 2019, 10:3896 (*the Corresponding author). https://doi.org/10.1038/s41467-019-11892-5. s.pngSchmidt W: F1000Prime Recommendation of [Li B et al., Nat Commun 2019 10(1):3896]. In F1000Prime, 10 Sep 2019; 10.3410/f.736508536.793564656.
Li B#, Kamiya T#, Kalmbach L, Yamagami M, Yamaguchi K, Shigenobu S, Sawa S, Danku JMC, Salt DE, Geldner N, Fujiwara T*. LOTR1 in Nutrient Transport through Organization of Spatial Distribution of Root Endodermal Barriers. Current Biology, 2017, 27:758-765.(#co-first authors). https://doi.org/10.1016/j.cub.2017.01.030. Referred to by Plant Biology: Building Barriers… in Roots. in Current Biology https://www.sciencedirect.com/science/article/pii/S0960982217301240.
Li G, Song H, Li B, Kronzucker HJ, Shi W*. Auxin resistant1 and PIN-FORMED2 protect lateral root formation in Arabidopsis under iron stress. Plant Physiology, 2015, 169:2608-2623.
Li B, Li G, Kronzucker HJ, Baluska F, Shi W*. Ammonium stress in Arabidopsis: signaling, genetic loci, and physiological targets. Trends in Plant Science, 2014, 19:107-114.
Zou N#, Li B#, Chen H, Su Y, Kronzucker HJ, Xiong L, Baluska F, Shi W*. GSA-1/ARG1 protects root gravitropism in Arabidopsis under ammonium stress. New Phytologist, 2013, 200:97-111(#co-first authors).
Li G, Li B, Dong G, Feng X, Kronzucker HJ, Shi W*. Ammonium-induced shoot ethylene production is associated with the inhibition of lateral root formation in Arabidopsis. Journal of Experimental Botany, 2013, 64: 1413-1425.
Li B, Li Q, Xiong L, Kronzucker HJ, Kraemer U, Shi W*. Arabidopsisplastid metalloprotease AMOS1/EGY1 integrates with ABA signaling to regulate global gene expression in response to ammonium stress. Plant Physiology,2012, 160:2040-2051.
Zou N, Li B, Dong G, Kronzucker HJ, Shi W*.Ammonium-induced loss of root gravitropism is related to auxin distribution and TRH1 function, and is uncoupled from the inhibition of root elongation in Arabidopsis. Journal of Experimental Botany, 2012, 63: 3777-3788.
Li B, Li Q, Su Y, Chen H, Xiong L, Mi G,Kronzucker HJ, Shi W*. Shoot-supplied ammonium targets the root auxin influx carrier AUX1 and inhibits lateral root emergence in Arabidopsis. Plant, Cell & Environment,2011, 34: 933-946.
Li Q#, Li B#, Kronzucker HJ, Shi W*. Root growth inhibition by NH4+in Arabidopsisis mediated by the root tip and is linked to NH4+ efflux and GMPase activity. Plant, Cell & Environment, 2010, 33:1529-1542 (#co-first authors).
（二）主持课题
The role of PLD1 in iron dependent root growth regulation. Austrian Science Fund (FWF)-Lise Meitner program (2/2016-1/2018, grant no. M 1826 Meitner-Program)
Analysis of low calcium sensitive mutants in Arabidopsis. Japan Society for the Promotion of Science (JSPS) foreign postdoctoral program (4/2013-3/2015, grant no. P11394)
拟南芥AMOS1基因介导的铵胁迫信号传导途径研究。国家自然科学基金青年项目（2013-2015）
AMOS1基因介导的植物过量铵胁迫信号响应分析及其与氮效率关系的初步探讨。中科院土壤所知识创新前沿项目（2012-2014） | | 个人简介 | 一、学习经历：
2004.9-2010.7, 中国科学院南京土壤研究所，植物营养学专业，博士，导师施卫明研究员
2000.9-2004.7, 南京农业大学农学院，农学专业，学士
二、工作经历：
2019.9 – 至今, 百人计划研究员，环境与资源学院，浙江大学
2018.2-2019.8, Research Associate, Assoc. Prof. Wolfgang Busch Group, Salk Institute for Biological Studies, USA
2016.2-2018.1, Lise-Meitner fellow, Dr.Wolfgang Busch Group, Gregor Mendel Institute, Austrian Academy of Sciences, Austria
2013.4-2016.1, JSPS Researcher / Project Assistant Professor, Prof. Toru Fujiwara Group, University of Tokyo, Japan
2012.8-2013.4, 中国科学院南京土壤研究所，施卫明研究员团队，助理研究员
2012.2-2012.7, Postdoc, Prof. Ute Kraemer Group, Ruhr University Bochum, Germany
2009.12-2012.1, 中国科学院南京土壤研究所, 施卫明研究员团队, 助理研究员 |
|
